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In healthy topics, the renal elimination of unchanged atazanavir was approximately 7% of the administered dose. In addition, it is recommended that didanosine be administered on an empty stomach; due to this fact, REYATAZ ought to be given (with food) 2 h earlier than or 1 h after didanosine buffered formulations. When coadministered with tenofovir, it's endorsed that REYATAZ 300 mg is given with ritonavir 100 mg and tenofovir 300 mg (all as a single dailydose with food). The FDA despatched a notice out this past week regarding drug-drug interactions between Reyataz (atazanavir) and tenofovir (Viread) and likewise Viagra and related drugs. The pharmacokinetics of atazanavir in pediatric patients are below investigation. Atazanavir is metabolized and eliminated primarily by the liver.

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